학술논문
Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson's disease and multiple system atrophy.
Document Type
Article
Author
Taha, Hash Brown; Hornung, Simon; Dutta, Suman; Fenwick, Leony; Lahgui, Otmane; Howe, Kathryn; Elabed, Nour; del Rosario, Irish; Wong, Darice Y.; Duarte Folle, Aline; Markovic, Daniela; Palma, Jose-Alberto; Kang, Un Jung; Alcalay, Roy N.; Sklerov, Miriam; Kaufmann, Horacio; Fogel, Brent L.; Bronstein, Jeff M.; Ritz, Beate; Bitan, Gal
Source
Subject
*PARKINSON'S disease
*EXTRACELLULAR vesicles
*MULTIPLE system atrophy
*DIFFERENTIAL diagnosis
*ALZHEIMER'S disease
*BIOMARKERS
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Language
ISSN
2047-9158
Abstract
The presented models do not include NfL The oEV:nEV pS129- -syn ratio increased similarly in the order HC < PD < MSA (Additional file 1: Fig. Consequently, unlike the oEV:nEV total -syn ratio, the oEV:nEV pS129- -syn ratio separated the groups only moderately. Serum/plasma nEV and oEV biomarker measurements for the HC, PD, and MSA groups. [Extracted from the article]