학술논문
Humoral immunity after second dose of BNT162b2 vaccine in Japanese communities: an observational cross-sectional study, Fukushima Vaccination Community Survey.
Document Type
Article
Author
Kobashi, Yurie; Kawamura, Takeshi; Shimazu, Yuzo; Zhao, Tianchen; Sugiyama, Akira; Nakayama, Aya; Kaneko, Yudai; Nishikawa, Yoshitaka; Omata, Fumiya; Takita, Morihito; Yamamoto, Chika; Yoshida, Makoto; Kosaka, Makoto; Murayama, Anju; Sugiura, Sota; Tanaka, Manato; Kawashima, Moe; Uchi, Yuna; Shindo, Joji; Oikawa, Tomoyoshi
Source
Subject
*COMMUNITIES
*VACCINATION complications
*HUMORAL immunity
*AGE groups
*COVID-19 vaccines
*VACCINATION
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Language
ISSN
2045-2322
Abstract
To reveal waning humoral immunity after second dose BNT162b2 vaccinations in a rural Japanese community and determine factors affecting antibody titers. We aimed to report Immunoglobulin G (IgG) antibody against the SARS-CoV-2 spike (S1) protein levels and neutralizing activity in a large scale community based cohort. Methods: Participants in the observational cross-sectional study received a second dose of vaccination with BNT162b2 (Pfizer/BioNTech) and were not previously infected with COVID-19. Questionnaire-collected data on sex, age, adverse vaccine reactions, and medical history was obtained. Results: Data from 2496 participants revealed that older age groups reached a low antibody titer 90–120 days after the second vaccination. Neutralizing activity decreased with age; 35 (13.3%) of those aged ≥ 80 years had neutralizing activity under the cut-off value. Neutralizing activity > 179 days from the second vaccination was 11.6% compared to that at < 60 days from the second vaccination. Significantly lower IgG antibody titers and neutralizing activity were associated with age, male sex, increased time from second vaccination, smoking, steroids, immunosuppression, and comorbidities. Conclusions: Antibody titer decreased substantially over time. Susceptible populations, older people, men, smokers, steroid users, immunosuppression users, and people with three or more comorbidities may require a special protection strategy. [ABSTRACT FROM AUTHOR]