학술논문
Bob1 maintains T follicular helper cells for long-term humoral immunity.
Document Type
Article
Author
Yanagi, Masahiro; Ikegami, Ippei; Kamekura, Ryuta; Sato, Tatsuya; Sato, Taiki; Kamiya, Shiori; Murayama, Kosuke; Jitsukawa, Sumito; Ito, Fumie; Yorozu, Akira; Kihara, Miho; Abe, Takaya; Takaki, Hiromi; Kawata, Koji; Shigehara, Katsunori; Miyajima, Satsuki; Nishikiori, Hirotaka; Sato, Akinori; Tohse, Noritsugu; Takano, Ken-ichi
Source
Subject
*T helper cells
*HUMORAL immunity
*CELL respiration
*IMMUNOGLOBULIN producing cells
*IMMUNOLOGIC memory
*RESPIRATION
*T cells
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Language
ISSN
2399-3642
Abstract
Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to humoral immunity, have garnered significant attention for unraveling immune mechanisms. This study shows the role of B-cell Oct-binding protein 1 (Bob1), a transcriptional coactivator, in Tfh cell regulation. Our investigation, utilizing conditional Bob1-deficient mice, suggests that Bob1 plays a critical role in modulating inducible T-cell costimulator expression and cellular respiration in Tfh cells. This regulation maintains the long-term functionality of Tfh cells, enabling their reactivation from central memory T cells to produce antibodies during recall responses. In a bronchial asthma model induced by house dust mite (HDM) inhalation, Bob1 is observed to enhance HDM-specific antibodies, including IgE, highlighting its pivotal function in Tfh cell regulation. Further exploration of Bob1-dependent mechanisms in Tfh cells holds promise for governing protective immunity and addressing immune-related disorders. Bob1 manages ICOS and cellular respiration in Tfh cells, ensuring the sustained generation of specific humoral responses. This likely contributes to persistent inflammation resulting from recurring allergen exposure. [ABSTRACT FROM AUTHOR]