학술논문
HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study.
Document Type
Article
Author
Source
Subject
*HIV
*SUB-Saharan Africans
*IMMUNOLOGICAL deficiency syndromes
*HLA histocompatibility antigens
*AFRICANA studies
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Language
ISSN
2328-8957
Abstract
The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval,.01–.48]; P =.009), which warrants further studies to explore its role on HIV-1–specific immunopathogenesis. [ABSTRACT FROM AUTHOR]