학술논문
Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells.
Document Type
Journal Article
Author
Source
Subject
Language
ISSN
1080-6040
Abstract
Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism. [ABSTRACT FROM AUTHOR]