학술논문
Clonal evolution of Philadelphia chromosome in acute myeloid leukemia after enasidenib treatment.
Document Type
Letter
Author
Source
Subject
*ACUTE myeloid leukemia
*CHROMOSOMES
*PROTEIN-tyrosine kinase inhibitors
*MYELODYSPLASTIC syndromes
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Language
ISSN
1042-8194
Abstract
Additionally, Alotaibi I et al. i reported three cases of Ph chromosome emergence after treatment with FLT3 inhibitors in patients with I FLT3-ITD i mutations [[5]]. Despite advances in the acute myeloid leukemia (AML) treatment armamentarium over the last 4 years, patients with relapsed/refractory (R/R) AML have dismal outcomes [[1]]. The p190 (e1a2) transcript was identified in 12/14 patients where RT-PCR testing was performed, including 6/8 AML patients and 3/3 MDS patients [[4]]. We previously reported a patient who developed secondary acquisition of a Ph chromosome with p190 transcripts after azacitidine treatment for relapsed AML [[12]]. [Extracted from the article]