학술논문
Aggressive neoplastic plasma cell growth with MLL gene rearrangement after high-dose therapy with autologous stem cell support for multiple myeloma.
Document Type
Article
Author
Source
Subject
*ANTIBODY diversity
*MULTIPLE myeloma
*STEM cells
*ETOPOSIDE
*LEUKEMIA
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Language
ISSN
0268-3369
Abstract
We report a case of a patient with IgA κ multiple myeloma (MM) mobilized with etoposide and subsequently receiving high-dose melphalan (HDM) with stem cell support. She relapsed rapidly post transplantation. Southern blot and fluorescent in situ hybridization analysis showed MLL gene rearrangement in the myeloma cells, which was not detected in the sample at diagnosis or in the PBSC harvested with etoposide plus G-CSF. These observations suggest that clonal rearrangement of the MLL gene is caused by etoposide. Patients with MM undergoing HDM with stem cell rescue may be at an increased risk of not only secondary leukemia, but also secondary genetic abnormalities in myeloma cells, especially those receiving priming with etoposide for peripheral blood stem cell collection. Bone Marrow Transplantation (2001) 27, 555–558. [ABSTRACT FROM AUTHOR]