학술논문
An RNA-based system to study hepatitis B virus replication and evaluate antivirals.
Document Type
Article
Author
Yingpu Yu; Schneider, William M.; Kass, Maximilian A.; Michailidis, Eleftherios; Acevedo, Ashley; Mosimann, Ana L. Pamplona; Bordignon, Juliano; Koenig, Alexander; Livingston, Christine M.; van Gijzel, Hardeep; Yi Ni; Ambrose, Pradeep M.; Freije, Catherine A.; Mengyin Zhang; Chenhui Zou; Kabbani, Mohammad; Quirk, Corrine; Jahan, Cyprien; Xianfang Wu; Urban, Stephan
Source
Subject
*HEPATITIS B virus
*REVERSE transcriptase
*VIRAL replication
*HEPATITIS C
*
*
*
Language
ISSN
2375-2548
Abstract
The article presents a study which described a method to initiate the replication of hepatitis B virus (HBV), a DNA virus, using synthetic RNA. Topics discussed include a test of whether HBV pregenomic RNA (pgRNA) could initiate the virus life cycle, the ability of HBV launch to identify drug resistance mutations de novo, and synthesis of HBV pgRNA.