학술논문
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of Beta-Amyloid Precursor Protein.
Document Type
Article
Author
Source
Subject
*PRESENILINS
*PROTEOLYSIS
*AMYLOID beta-protein
*ALZHEIMER'S disease
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Language
ISSN
0021-9258
Abstract
Studies the critical role of presenilins in the proteolysis of beta-amyloid precursor protein (beta-APP) to generate beta-amyloid, a peptide important in the pathogenesis of Alzheimer's disease. Biogenesis of beta-APP-containing vesicles from the trans-Golgi network and the endoplasmic reticulum; Analysis of pertinent topics and relevant issues; Implications on membrane transport, structure, function and biogenesis.