학술논문
Absence of Mutations in the CDKN2 Binding Site of CDK4 in Childhood Acute Lymphoblastic Leukemia.
Document Type
Article
Author
Source
Subject
*CYCLIN-dependent kinases
*BINDING sites
*ACUTE myeloid leukemia in children
*CARCINOGENESIS
*RETINOBLASTOMA
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Language
ISSN
1042-8194
Abstract
Reports on the absence of point mutations in the cyclin-dependent-kinase (CDK) binding site of CDK4 in childhood acute lymphoblastic leukemia. Influence of alterations in the retinoblastoma protein (pRB) pathway in tumorigenesis; Patient characteristics; Possible mechanisms that account for pRB disruption.