학술논문
Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet.
Document Type
Article
Author
Source
Subject
*ETHANOL
*CYTOCHROME P-450 CYP2E1
*OXIDATIVE stress
*FOOD consumption
*LOW-carbohydrate diet
*LABORATORY rats
*SUCROSE
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Language
ISSN
0148-0545
Abstract
Expression of cytochrome P4502E1 (CYP2E1) is very much influenced by nutritional factors, especially carbohydrate consumption, and various results concerning the expression of CYP2E1 were obtained with a low-carbohydrate diet. This study describes the effects of ethanol treatment on CYP2E1 levels and its relationship with oxidative stress using a balanced standard diet to avoid low or high carbohydrate consumption. Rats were fed for 1, 2, 3, or 4 weeks a commercial diet plus an ethanol-sucrose solution. The results have shown that ethanol administration was associated with CYP2E1 induction and stabilization without related oxidative stress. Our findings suggest that experimental models with a low-carbohydrate/high-fat diet produce some undesirable CYP2E1 changes that are not present when a balanced standard diet is given. [ABSTRACT FROM AUTHOR]