학술논문
Lack of Significant Elevation of Myeloid-Derived Suppressor Cells in Peripheral Blood of Chronically Hepatitis C Virus-Infected Individuals.
Document Type
Article
Author
Source
Subject
*HEPATITIS C virus
*SUPPRESSOR cells
*CD8 antigen
*IMMUNOREGULATION
*T cells
*GRANULOCYTES
*VIRAL load
*PHYSIOLOGY
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Language
ISSN
0022-538X
Abstract
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunosuppressive function. Compared to the level in healthy controls (HC), no elevation of MDSC in chronic hepatitis C (cHEP-C) patients was found, and there was no difference in MDSC based on genotype or viral load (P>0.25). Moreover, MDSC of cHEP-C patients inhibited CD8 T cell function as efficiently as MDSC of HC did. Since we detected neither quantitative nor qualitative differences in MDSC of cHEP-C patients relative to those of HC, we postulate that MDSC in peripheral blood are most likely not significant regarding immune dysfunction in cHEP-C. [ABSTRACT FROM AUTHOR]