부산대학교 도서관

Asthma is a diverse illness with many, overlying phenotypes. Biomarkers are currently being inspected and developed to distinguish the disease phenotypes and to categorize the responders to appropriate treatments. Recently, an extracellular matrix protein, namely Periostin, has been identified as a novel biomarker for asthma. Periostin production and release is facilitated by IL-4 and IL-13 in the epithelial cells of the airways and the fibroblasts in lungs. It has been established as a significant biomarker of Th2-mediated airway irritation as well as a diagnostic marker for eosinophilic airway diseases. It has also been on trial in attempts to predict the response in asthmatics who are on inhaled corticosteroids. However, additional inquiries are warranted to establish the exact role of Periostin in allergic airway disease. The articles for this review were collected using key words like ‘asthma’, ‘Periostin’, ‘inhalational corticosteroids’, ‘Type 2 inflammation’ making use of search engines like Google scholar, Medline, Pubmed. It is hoped that this review will aid the practitioners and asthmatics to understand the role of Periostin in detecting steroid hypo-responsive asthma. [ABSTRACT FROM AUTHOR]