부산대학교 도서관

The elimination of onchocerciasis through community-based Mass Drug Administration (MDA) of ivermectin (Mectizan) is hampered by co-endemicity of Loa loa, as individuals who are highly co-infected with Loa loa parasites can suffer serious and occasionally fatal neurological reactions from the drug. The test-and-not-treat strategy of testing all individuals participating in MDA has some operational constraints including the cost and limited availability of LoaScope diagnostic tools. As a result, a Loa loa Antibody (Ab) Rapid Test was developed to offer a complementary way of determining the prevalence of loiasis. We develop a joint geostatistical modelling framework for the analysis of Ab and Loascope data to delineate whether an area is safe for MDA. Our results support the use of a two-stage strategy, in which Ab testing is used to identify areas that, with acceptably high probability, are safe or unsafe for MDA, followed by Loascope testing in areas whose safety status is uncertain. This work therefore contributes to the global effort towards the elimination of onchocerciasis as a public health problem by potentially reducing the time and cost required to establish whether an area is safe for MDA. Author summary: Considering the serious adverse events that occur in individuals with high intensity of Loa loa parasite when being treated with ivermectin during the MDA program for the elimination of onchocerciasis, there is need for a comprehensive, safe and cost-effective strategy to delineate village or communities that are safe for MDA. In this study, we propose a hybrid strategy that uses information from the Loa antibody rapid test and the LoaScope diagnostic test to delineate whether an area is safe for MDA. We developed a joint geostatistical modelling framework that exploits both the association between antibody and LoaScope responses at community-level and the spatial correlation of the Loa loa prevalence surface to determine if the risk of observing individuals with high-intensity infections in a village or community is sufficiently low. Our results support the use of a two-stage strategy in which antibody test is used first as a screening tool and only those communities for which safety are in doubt are followed up with confirmatory LoaScope testing. [ABSTRACT FROM AUTHOR]