부산대학교 도서관

Background: Due to advances in medical care the great majority of children with complex Congenital Heart Disease (CHD) survive into adulthood. It has previously been reported that children with chronic disease are at risk of low bone mineral density (BMD) and a recent study on children with univentricular hearts showed lower BMD compared to reference data. If this also applies to an adult population of complex CHD is not known. Hypothezis: The aim of the present study was to investigate the BMD and bone mineral content (BMC) in adults with various complex CHD. Our hypothesis was that adults with complex CHD would have lower BMD and BMC compared to healthy controls and published reference values. Methods: The total body BMD and BMC was examined, using Dual-Energy X-ray Absorptiometry (DXA), in 73 adult patients with complex CHD (mean age 35.8±14.3, women n=22) and 73 healthy age and gender matched controls. Results: The adults with complex CHD (n=73) were shorter than their controls (173±10cm vs. 177±9cm, p =0.018). The men (n=51) weighed less (76±11kg vs. 82±12kg, p =0.013) whereas the women (n=22) did not differ in weight compared to the healthy peers (68±12kg vs. 64±8kg, p =0.23). Furthermore, the adults with CHD had lower total body BMD and BMC (1.18±0.12g/cm2 vs. 1.26±0.11g/cm2, p <0.001 and 2.6±0.5kg vs. 2.9±0.5kg, p <0.001) in comparison to the controls. Consistent with that, they also had a lower total body BMD Z-score (0.23±1.03 vs 0.92±1.03 p <0.001) These findings persisted in analysis of men and women separately. Conclusion: Adults with complex CHD have a reduced total body BMD, BMC and BMD Z-score compared to healthy peers. This may be due to their CHD however, the specific mechanisms remain unclear. The risk of osteoporosis is low in this rather young population but is assumed to increase with ageing. Our findings imply that it may be motivated to evaluate development of BMD over time in order to prevent future development of osteoporosis in this population. [ABSTRACT FROM AUTHOR]