부산대학교 도서관

Simple Summary: Although some nutrients, foods, and food groups have been linked to prostate cancer (PCa), their relationship remains unclear. In this sense, dietary patterns allow a global approach to diet. This study evaluated the role of dietary patterns on PCa by tumor aggressiveness and extension. A total of 428 incident PCa cases and 393 controls were included. When comparing scores in the highest vs. lowest tertiles, an unhealthy dietary pattern was associated with higher odds of PCa. This association was observed only for PCa ISUP 1 or 2 tumors and localized PCa cases. We were unable to establish a clear association between Western or Mediterranean dietary patterns and PCa. These results increase the evidence of a possible relationship between diet and PCa. Therefore, future recommendations should focus on avoiding unhealthy dietary patterns. The etiology of prostate cancer (PCa) remains uncertain, and the role of diet is unclear. We aimed to evaluate the role of diet, through dietary patterns, on PCa, considering tumor aggressiveness and extension. The CAPLIFE study is a population-based case-control study including a total of 428 incident PCa cases and 393 controls aged 40–80 years. Dietary information was collected through a validated food frequency questionnaire. Three dietary patterns were identified through principal component analysis: "Mediterranean," "Western," and "Unhealthy," which were categorized into tertiles according to the control group cutoff points. Tumor aggressiveness and extension was determined. Logistic regression models were used to assess the association between dietary patterns and PCa. High adherence to an unhealthy dietary pattern was associated with higher odds of PCa, ORT3vsT1 = 1.52 (95% CI 1.02–2.27), especially for cases with ISUP 1–2 and localized PCa tumors. This association was not observed with a Western or Mediterranean pattern. In conclusion, adherence to an unhealthy diet appears to be associated with higher odds of PCa, especially for cases with ISUP 1–2 and localized PCa tumors. [ABSTRACT FROM AUTHOR]