학술논문
Aggressive prostate myxoid mesenchymal neoplasm with novel CRTC1::NCOA2 fusion.
Document Type
Article
Author
Source
Subject
*SOFT tissue tumors
*ANDROGEN receptors
*TUMORS
*PROSTATE
*NUCLEAR receptors (Biochemistry)
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Language
ISSN
0309-0167
Abstract
This article reports on a rare case of an aggressive myxoid mesenchymal neoplasm in the prostate with a novel CRTC1::NCOA2 fusion. The patient was a 24-year-old male with Goldenhar syndrome, a congenital disorder. The tumor was initially attributed to detrusor sphincter dyssynergia, but imaging later revealed a 4.6 cm prostate mass. Biopsies showed a low-grade hypocellular myxoid tumor, and subsequent surgery revealed a 6.3 cm tumor with worrisome morphology. The tumor was positive for SMA, CD117, and NSE, but negative for other markers. Genetic analysis revealed a fusion between CRTC1 and NCOA2 genes. This fusion has not been previously described in prostate tumors. The authors note that more cases are needed to better understand these rare neoplasms. [Extracted from the article]