학술논문
Principal Component Analysis Differentiates the Receptor Binding Profiles of Three Antipsychotic Drug Candidates from Current Antipsychotic Drugs.
Document Type
Article
Author
Source
Subject
*RADIOLIGAND assay
*ANTIPSYCHOTIC agents
*WEIGHT gain
*CELL receptors
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Language
ISSN
0022-2623
Abstract
The receptor binding affinities of the three drug candidates 1(SLV310), 2(SLV313), and 3(SLV314) were positioned against the results from nine (a)typical antipsychotic drugs. The receptor binding data from sixteen monoaminergic receptors served as the input in a principal component analysis (PCA). The PCA outcome revealed a unique binding profile of 1, 2, and 3as compared with the reference compounds 4−8and 10−12. The weight gain inducing antipsychotics 6−8clustered in the PCA by scoring strongly negative for factor 1. The hyperprolactinaemia related antipsychotics 4, 5, 10, and 12clustered by their negative scores for factor 2. [ABSTRACT FROM AUTHOR]