부산대학교 도서관

배경 Listeria monocytogenes is the causative agent of listeriosis, highly fatal foodborne diseases implicated in sporadic cases and outbreak worldwide. L. monocytogenes infection is a notifiable declaration disease, especially in USA and European countries. However, human infections by L. monocytogenes are rare in Korea and information on this infection has been scarce among the Korean population. 방법 We report surveillance of L. monocytogenes in Korea using whole genome sequencing from 2012 to 1st half of 2020. A total of 24 clinical isolates are isolated and a first and a second outbreak associated isolates which were occurred recent in Korea were included. 결과 The predominant serotypes were 1/2a and 1/2b, which accounted for 79%. The prevalent STs were ST155, ST224, and ST87, accounting for 62.5% of the isolates. The STs of two isolates which was asso- ciated with the two different outbreaks were ST224 and the cgMLST analysis indicated that they are same clonal strain. The analysis of Listeria Pathogenicity Islands (LIPIs) indicated that distribution of LIPIs were associated with lineages and STs. The phylogenetic tree based on cgMLST showed that Korean isolates are clustered those from USA, Europe, South America, especially there is less than 20 allelic differences with those from Taiwan. 결론 There is different distribution of serotypes when they are compared to the USA and Europe. However, prevalent STs in Korea are widely distributed throughout the world. This study improves our understanding of genetic diversity of clinical L. monocytogenes in Korea for the first time. [ABSTRACT FROM AUTHOR]