부산대학교 도서관

In this study, the role of hydro-alcoholic extract of BS on obesity and its related hormones neuropeptide-Y (NPY), agouti protein, leptin, insulin, ghrelin, cholecystokinin, amylin, orexin, obestatin, adiponectin, chemerin, omentin-1, epinephrine, resistin, kidney and liver function markers and antioxidants were investigated. Thirty-six male Wistar rats were divided into six groups: Control, Sham, and hydroalcoholic BS extract groups (four doses): 200, 400, 800, and 1600 mg/kg. The extract was fed by gavage, and after 29 days, blood samples and tissues were taken. Rats ELISA kits were used to measure adiponectin, obestatin, resistin, orexin A, insulin, epinephrine, AgRP, omentin, chemerin, amylin, agitation, NPY, and ghrelin. In addition, we measured leptin, cholecystokinin, lipid profile factors, kidney and liver function markers and antioxidants. Evaluating weight changes demonstrated that using BS help animals to lose weight significantly in groups received 800 and 1600 mg/kg BS. Leptin, adiponectin, AgRP, obestatin, CCK, chemerin, adiponectin, and total antioxidants showed a significant increase compared to the control group, while ghrelin, lipid profile, resistin, orexin A, omentin, amylin, epinephrine, MDA, and NPY were reduced at treatment groups. Using BS affected patients’ kidney and liver function. Higher doses of BS was more effective than lower. The blood creatinine was not affected by BS. These findings suggest that BS reduces NPY and orexin, thereby prevent appetite. BS also reduces ghrelin and increases obestatin, and cholecystokinin; BS has the potency to alter adipose tissue secretory factors to help with weight loss and reduce the lipid profile, which affects patients’ health. [ABSTRACT FROM AUTHOR]