학술논문
Alpha-Synuclein mRNA Levels Correspond to Beck Depression Inventory Scores in Females with Eating Disorders.
Document Type
Article
Author
Source
Subject
*EATING disorders
*MESSENGER RNA
*DIAGNOSIS of mental depression
*APPETITE disorders
*NEUROTRANSMITTERS
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Language
ISSN
0302-282X
Abstract
α-Synuclein (α-Syn) is a neuronal protein involved in the regulation of brain serotonin and dopamine levels. We analyzed the peripheral expression of α-Syn mRNA and Beck Depression Inventory scores in female patients suffering from anorexia nervosa (n = 18) or bulimia nervosa (n = 24). We found a significant positive association between α-Syn mRNA expression and the total scores of the Beck Depression Inventory (linear regression; R2 = 0.20; p = 0.003). α-Syn may play a pathophysiological role in depressive symptoms associated with eating disorders. Further investigations in patients with depression as a sole diagnosis are needed to support its role in the pathogenesis of major depression. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]