학술논문
A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis.
Document Type
Article
Author
Feys, Simon; Heylen, Jannes; Carvalho, Agostinho; Van Weyenbergh, Johan; Wauters, Joost; on behalf of the Variomic Study Group; Gonçalves, Samuel M.; Cunha, Cristina; Debaveye, Yves; Hermans, Greet; Humblet-Baron, Stephanie; Jacobs, Cato; Lambrechts, Diether; Mombaerts, Peter; Lagrou, Katrien; Meersseman, Philippe; Menezes, Soraya Maria; Peetermans, Marijke; Rocha-Pereira, Joana; Seldeslachts, Laura
Source
Subject
*GENE expression
*PULMONARY eosinophilia
*GENE ontology
*BRONCHOALVEOLAR lavage
*PULMONARY aspergillosis
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Language
ISSN
0342-4642
Abstract
Given this finding, we assessed whether the protein VEGF is associated with IAPA mortality as well using a dataset of BAL VEGF levels obtained from 40 patients, of whom 38 were included in the gene expression dataset [[2]]. We conclude that decreased lower respiratory tract expression of genes related to anti I Aspergillus i immunity and increased VEGF levels and VEGF-related signaling are associated with increased mortality in IAPA patients. [Extracted from the article]