부산대학교 도서관

Objective: Our objective was to characterize vaping behavior and nicotine intake during ad libitum e-cigarette access. Methods: Thirteen adult e-cigarette users had 90 minutes of videotaped ad libitum access to their usual e-cigarette. Plasma nicotine was measured before and every 15 minutes after the first puff; subjective effects were measured before and after the session. Results: Average puff duration and interpuff interval were 3.5±1.4 seconds (±SD) and 118±141 seconds, respectively. Overall, 12% of puffs were unclustered puffs, and 43%, 28%, and 17% were clustered in groups of 2-5, 6-10, and >10 puffs, respectively. On average, 4.0±3.3 mg of nicotine was inhaled; the maximum plasma nicotine concentration (Cmax) was 12.8±8.5 ng/mL. Among the 8 tank users, whereas the number of puffs was positively correlated with the amount of nicotine inhaled, Cmax, and area under the plasma nicotine concentration-time curve (AUC0→90min), the interpuff interval was negatively correlated with Cmax and AUC0→90. Conclusion: Vaping patterns differ from cigarette smoking. Plasma nicotine levels were consistent with intermittent dosing of nicotine from e-cigarettes compared to the more bolus dosing from cigarettes. Differences in delivery patterns and peak levels of nicotine achieved could influence the addictiveness of e-cigarettes compared to conventional cigarettes. [ABSTRACT FROM AUTHOR]