학술논문
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity.
Document Type
Article
Author
Castela, Inês; Morais, Juliana; Barreiros-Mota, Inês; Silvestre, Marta P.; Marques, Cláudia; Rodrigues, Catarina; Ismael, Shámila; Araújo, João R.; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Monteiro, Rosário; Coutinho, Sílvia Ribeiro; Calhau, Conceição; Martins, Cátia; Faria, Ana; Pestana, Diogo; Teixeira, Diana
Source
Subject
*LEPTIN
*ADIPOKINES
*INSULIN resistance
*ADIPONECTIN
*ADIPOSE tissues
*OBESITY
*BODY mass index
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Language
ISSN
0193-1849
Abstract
Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the reliability of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4 ± 3.7 kg/m²) (NCT02169778). With the use of a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), it was observed that 48.6% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep, and waist-to-hip ratio (P < 0.001), AdipoQ/Lep being the strongest independent predictor (Beta = -0.449, P < 0.001). A lower AdipoQ/Lep was correlated with higher body mass index (Rs = -0.490, P < 0.001), body fat mass (Rs = -0.486, P < 0.001), waist-to-height ratio (Rs = -0.290, P = 0.037), and plasma resistin (Rs = -0.365, P = 0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity. [ABSTRACT FROM AUTHOR]