학술논문
An Unusual Rearrangement of Pyrazole Nitrene and Coarctate Ring-Opening/Recyclization Cascade: Formal CH–Acetoxylation and Azide/Amine Conversion without External Oxidants and Reductants.
Document Type
Article
Author
Source
Subject
*PYRAZOLES
*REDUCING agents
*OXIDIZING agents
*AMINO group
*AMINES
*RING formation (Chemistry)
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Language
ISSN
1420-3049
Abstract
We report an unusual transformation where the transient formation of a nitrene moiety initiates a sequence of steps leading to remote oxidative C–H functionalization (R–CH3 to R–CH2OC(O)R') and the concomitant reduction of the nitrene into an amino group. No external oxidants or reductants are needed for this formal molecular comproportionation. Detected and isolated intermediates and computational analysis suggest that the process occurs with pyrazole ring opening and recyclization. [ABSTRACT FROM AUTHOR]