부산대학교 도서관

Simple Summary: Analyzing real-world data from the OneFlorida+ Clinical Research Network, we examined the impact of ADRD diagnosis and race–ethnicity on mammography use in breast cancer screening (BCS)-eligible women. We found that BCS-eligible women with Alzheimer's disease (AD) and AD-related dementias (ADRD) were more likely to undergo a mammography than the BCS-eligible women without ADRD. Stratified by race–ethnicity, BCS-eligible Hispanic women with ADRD were more likely to undergo a mammography, whereas BCS-eligible non-Hispanic black and non-Hispanic other women with ADRD were less likely to undergo a mammography. Breast cancer screening (BCS) with mammography is a crucial method for improving cancer survival. In this study, we examined the association of Alzheimer's disease (AD) and AD-related dementias (ADRD) diagnosis and race–ethnicity with mammography use in BCS-eligible women. In the real-world data from the OneFlorida+ Clinical Research Network, we extracted a cohort of 21,715 BCS-eligible women with ADRD and a matching comparison cohort of 65,145 BCS-eligible women without ADRD. In multivariable regression analysis, BCS-eligible women with ADRD were more likely to undergo a mammography than the BCS-eligible women without ADRD (odds ratio [OR] = 1.19, 95% confidence interval [CI] = 1.13–1.26). Stratified by race–ethnicity, BCS-eligible Hispanic women with ADRD were more likely to undergo a mammography (OR = 1.56, 95% CI = 1.39–1.75), whereas BCS-eligible non-Hispanic black (OR = 0.72, 95% CI = 0.62–0.83) and non-Hispanic other (OR = 0.65, 95% CI = 0.45–0.93) women with ADRD were less likely to undergo a mammography. This study was the first to report the impact of ADRD diagnosis and race–ethnicity on mammography use in BCS-eligible women using real-world data. Our results suggest ADRD patients might be undergoing BCS without detailed guidelines to maximize benefits and avoid harms. [ABSTRACT FROM AUTHOR]