학술논문
Association of IL‐33 in modeling type‐2 airway inflammation and pulmonary emphysema in mice.
Document Type
Article
Author
Source
Subject
*PULMONARY emphysema
*INTERLEUKIN-33
*PNEUMONIA
*INFLAMMATION
*LUNGS
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Language
ISSN
2050-4527
Abstract
We developed pulmonary emphysema and a type 2 airway inflammation overlap mouse model. The bronchoalveolar lavage (BAL) interleukin 13 (IL‐13), IL‐4, and IL‐5 levels in the overlap model were higher than in the pulmonary emphysema model and lower than in the type 2 airway inflammation model, but IL‐33 level in the lung was higher than in other models. IL‐33 and interferon‐γ (IFNγ) in lungs may control the severity of a type 2 airway inflammation in lung. [ABSTRACT FROM AUTHOR]