학술논문
Effectiveness of Using the Modified Checklist for Autism in Toddlers in Two-Stage Screening of Autism Spectrum Disorder at the 18-Month Health Check-Up in Japan.
Document Type
Article
Source
Subject
*DIAGNOSIS of autism
*MEDICAL screening -- Law & legislation
*ANALYSIS of variance
*CHI-squared test
*CONFIDENCE intervals
*EPIDEMIOLOGY
*INTERVIEWING
*LONGITUDINAL method
*MEDICAL protocols
*MEDICAL screening
*RESEARCH funding
*STATISTICS
*DATA analysis
*PREDICTIVE tests
*RESEARCH methodology evaluation
*DATA analysis software
*DESCRIPTIVE statistics
*CHILDREN
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Language
ISSN
0162-3257
Abstract
To determine whether the Modified Checklist for Autism in Toddlers (M-CHAT) in conjunction with the routine 18-month health check-up identifies Japanese toddlers with autism spectrum disorder (ASD). Two-stage screening using the M-CHAT was conducted with 1,851 children attending the check-up. Final ASD diagnosis was confirmed at age ≥3 years. Screening identified 20/51 children with ASD: 12/20 true positives were developmentally delayed, whereas 16/22 false negatives were high-functioning. Sensitivity was 0.476, specificity 0.986, positive predictive value 0.455, and likelihood ratio 33.4 for children with ASD. With a few modifications, M-CHAT screening successfully detected toddlers with ASD with and without developmental delay and is a promising screening tool to complement existing community surveillance. [ABSTRACT FROM AUTHOR]