학술논문

Paradigm shifts in the management of poor-risk chronic lymphocytic leukemia.
Document Type
Article
Source
Leukemia & Lymphoma. Jun2015, Vol. 56 Issue 6, p1626-1635. 10p.
Subject
*CHRONIC lymphocytic leukemia
*CHRONIC lymphocytic leukemia treatment
*STEM cell transplantation
*GRAFT versus host disease
*FLUDARABINE
*CANCER risk factors
Language
ISSN
1042-8194
Abstract
With the growing complexity of treatment options for chronic lymphocytic leukemia (CLL) and variables that influence the underlying biology of this disease, providing allogeneic stem cell transplant (alloSCT) to appropriate candidates poses a challenge for transplant physicians. Novel small molecule inhibitors hold unprecedented promise for poor-risk subgroups, which will likely alter decision-making and referral patterns for transplant. In this review, we analyze what is known and may still remain true about indications for transplant based on outcomes reported in the literature recently and over the last decade. [ABSTRACT FROM AUTHOR]