부산대학교 도서관

Objectives: To evaluate the effects of sarcopenia and excess visceral fat accumulation on early urinary function after I‐125 low‐dose‐rate brachytherapy for prostate cancer. Methods: We retrospectively reviewed consecutive patients who underwent brachytherapy for prostate cancer. Pre‐treatment computed tomography was used to measure skeletal muscle index at the L3 level to assess sarcopenia and visceral fat area at the umbilical level. The International Prostate Symptom Score and the University of California Los Angeles Prostate Cancer Index were used to assess quality of life during the 24 months after brachytherapy. Logistic regression analysis was used to examine whether sarcopenia and excess visceral fat accumulation had clinically significant effects on post‐treatment quality of life. Results: Among 246 patients, 92 (37.4%) were stratified into the sarcopenia group and 141 (57.3%) into the excess visceral fat accumulation group. The sarcopenia group had significantly lower University of California Los Angeles Prostate Cancer Index urinary function than the non‐sarcopenia group 24 months post‐brachytherapy. The excess visceral fat accumulation group had significantly poorer International Prostate Symptom Score total, storage, and voiding scores than the non‐excess accumulation group 12 months post‐brachytherapy. In the multivariate analysis, sarcopenia had a clinically significant adverse effect on the University of California Los Angeles Prostate Cancer Index urinary function at 12 months. Excess visceral fat accumulation had a clinically significant adverse effect on the International Prostate Symptom Score voiding and storage scores at 12 months. Conclusions: Sarcopenia and excess visceral fat accumulation negatively affect urinary function early after I‐125 low‐dose‐rate brachytherapy for prostate cancer. [ABSTRACT FROM AUTHOR]