부산대학교 도서관

Zearalenone (ZEN) is a mycotoxin that contaminates crops worldwide and whose toxic adverse effects are well documented. This study aims to evaluate the protective effect of gallic acid (GA) against biochemical, oxidative, inflammatory, and pathological changes in ZEN treated rats' hepatorenal system. Wistar rats (n = 50; 150 ± 30 g) were randomly grouped into five cohorts (= 10) specifically: Control (rat chow); ZEN alone (100 µg/kg; per os), GA alone (40 mg/kg; per os), ZEN + GA1 (100 µg/kg + 20 mg/kg per os) and ZEN + GA2 (100 µg/kg + 40 mg/kg per os) and the study was for 28 successive days. Upon terminal sacrifice, biomarkers of hepatorenal function and oxidative stress were analyzed. An assessment of cytokine levels (IL-1β, IL-10) and histopathology of the liver and kidneys was also performed. Relative to the control, serum levels of urea, creatinine, and hepatic transaminases increased significantly (p < 0.05) in the ZEN alone group and reduced in groups co-treated with GA. ZEN treatment further resulted in decreases in the rat's antioxidant status. The increase in the reactive oxygen and nitrogen species (RONS) and lipid peroxidation (LPO) levels caused by ZEN exposure was reduced by GA in a dose-dependent manner (p < 0.05). Furthermore, ZEN-mediated increase in nitric oxide (NO), xanthine oxidase (XO), IL-1β, and myeloperoxidase (MPO) levels and suppression of IL-10 levels were reversed in the liver and kidney of GA co-treated rats. The extent of ZEN-mediated hepatorenal lesions was reduced in rats co-treated with GA. Our findings suggest that GA effectively abated biochemical, oxido-inflammatory and histological alteration caused by ZEN exposure, limiting ZEN toxicity and cellular damage in rats' hepatic and renal tissues. [ABSTRACT FROM AUTHOR]