부산대학교 도서관

Background: Breast cancer is the most common malignancy in women, whereas metastases to the breast from extra mammary malignancies are very rare, accounting for only 0.43% of all malignant breast tumors, with an often poor prognosis: about 80% of patients dying within 1 year of diagnosis. Case report: We present two cases of female patients treated for extra mammary malignancies which developed breast metastases. The first patient, 59 years old, was diagnosed in April 2014 with small cell lung carcinoma, sub diaphragmatic lymph nodes and bone metastases, developed under chemotherapy breast metastasis. This was revealed on a clinical examination in December 2014 and certified in March 2015 by immunohistochemistry as a mammary metastasis of small cell lung carcinoma. The second patient, 45 years old, was diagnosed in February 2012 with sigmoid adenocarcinoma and bilateral ovarian metastases. In January 2015 she performed a digital mammography and a breast tumour was discovered. This was certified in March 2015 by immunohistochemistry as a mammary adenocarcinoma metastasis, intestinal type (colonic). Conclusions: The breast is an uncommon site for metastatic disease. The most frequent source of the metastatic breast lesions are the contralateral breast, lymphomas, melanomas, prostate cancers, lung carcinomas, ovarian carcinomas, renal cell carcinomas, and intestinal tumours. It is important to be acutely aware of both common and uncommon metastases to the breast and to include these appropriately in the differential diagnosis for the optimal patient management. [ABSTRACT FROM AUTHOR]