학술논문
Cp*Rh(III)‐Catalyzed C8 C−H Alkylation of Quinoline N‐Oxides with Diazo Meldrum's Acid.
Document Type
Article
Author
Source
Subject
*ALKYLATION
*QUINOLINE
*CATALYST synthesis
*RHODIUM
*ACIDS
*RHODIUM compounds
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Language
ISSN
1434-193X
Abstract
A rhodium(III)‐catalyzed, site‐selective, C−H alkylation of quinoline N‐oxides at C8 using bench‐stable and commercially available diazo Meldrum's acid is reported. This straightforward protocol employs a widely available catalyst and enables the synthesis of a variety of 8‐quinolinylacetic acid esters on gram scale without necessitating the preparation and use of an excess of air‐sensitive organometallic reagents. [ABSTRACT FROM AUTHOR]