학술논문
Synthesis of N-methylpiperidin-4-one derivatives and evaluation of their anti-endometrial cancer activity.
Document Type
Article
Author
Source
Subject
*PIPERIDINE
*ALIPHATIC amine synthesis
*ANTINEOPLASTIC agents
*X-ray crystallography
*PHENYL compounds
*CRYSTAL structure
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Language
ISSN
1070-3632
Abstract
Four novel N-methylpiperidin-4-one derivatives were synthesized and characterized by IR, H NMR, HRMS, and single crystal X-ray crystallography. The anticancer activity of these compounds was studied on five human endometrial cancer cell lines (RL-95-2, HEC-1A, HEC-1B, AN3CN and HECCL-1). Efficient antitumor effect was found for the 3,5-difluorophenyl- and 3-cyanophenyl-substituted derivatives. [ABSTRACT FROM AUTHOR]