학술논문
BTEX exposure and its body burden pose differential risks for asthma and its phenotypic clusters.
Document Type
Article
Author
Hsu, Yuan‐Ting; Wu, Chao‐Chien; Wang, Chin‐Chou; Chung, Wen‐Yu; Sheu, Chau‐Chyun; Yang, Yi‐Hsin; Cheng, Ming‐Yen; Lai, Ruay‐Sheng; Leung, Sum‐Yee; Lin, Chi‐Cheng; Wei, Yu‐Feng; Lin, Ching‐Hsiung; Lin, Sheng‐Hao; Hsu, Jeng‐Yuan; Huang, Wei‐Chang; Tseng, Chia‐Cheng; Lai, Yung‐Fa; Cheng, Meng‐Hsuan; Chen, Huang‐Chi; Yang, Chih‐Jen
Source
Subject
*BODY burden
*ASTHMA
*ATOPY
*WHEEZE
*LIQUID chromatography-mass spectrometry
*
*
*
*
Language
ISSN
0105-4538
Abstract
Exposure to BTEX has been suggested to be a potential risk factor for asthma,[[1], [3]] a heterogeneous disease with unclear etiology, but its individual risk for adult asthma and its phenotypic clusters remains unclear. An hourly grid-scale model was utilized to estimate the residence-based ambient air BTEX levels and the time-lag effect (lag-0, lag-1, lag-2, lag-3, lag-4, and lag-5) on the daily asthma ERVs and outpatient visits. Abbreviations 2,4-DPMA N -acetyl- S -(2,4-dimethylbenzene)- l -cysteine 4-HNE 4-hydroxynonenal BMA N -acetyl- S -(benzyl)- l -cysteine BTEX benzene, toluene, ethylbenzene, and xylene C1P ceramide-1-phosphate ERV emergency room visit HEL N -(hexanoyl)-lysine LC-MS liquid chromatography-tandem mass spectrometry NHIRD National Health Insurance Research Database PGA phenylglyoxylic acid PMA N -acetyl- S -phenyl- l -cysteine RR relative risk S1P sphingosine-1-phosphate SL sphingolipid VOCs volatile organic compounds In a combined population-based and case-control study, exposure to benzene, toluene, ethylbenzene, and xylene (BTEX), particularly benzene, concomitant with increased oxidative stress and sphingolipid dysregulation, posed a significant, but differential, risk for current asthma, its severity, and phenotypic clusters. [Extracted from the article]