부산대학교 도서관

Sentinel lymph node biopsy (SLNB) provides important prognostic information for early‐stage melanomas. However, statistics regarding the survival comparison between SLNB and nodal observation in Asia, where acral lentiginous melanoma (ALM) predominates, are limited. This study aimed to identify if SLNB offered survival benefits over nodal observation in early‐stage melanomas in Taiwan. The retrospective study included 227 patients who met the SLNB criteria according to the National Comprehensive Cancer Network guidelines and were treated at National Taiwan University Hospital from June 1997 to June 2021. Survival analysis was performed using Kaplan–Meier curves and Cox proportional hazards regression models. Of the study population, ALM accounted for 73.1%; 161 patients (70.9%) underwent SLNB and 66 patients (29.1%) were under nodal observation. Multivariate analysis showed significantly improved melanoma‐specific survival (hazard ratio [HR], 0.6; p =.02) in the SLNB group. Among those who underwent completion lymph node dissection (CLND), the non‐sentinel node positivity rate was 44.4%. Immediate CLND resulted in significantly longer melanoma‐specific survival and distant‐metastasis‐free survival (DMFS) compared to nodal observation. (HR, 0.2; p =.01 for melanoma‐specific survival. HR, 0.3; p =.046 for DMFS). In conclusion, SLNB may provide survival benefits of cutaneous melanoma over nodal observation in the Taiwanese population. [ABSTRACT FROM AUTHOR]