학술논문
Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury.
Document Type
Article
Author
Hossain, Iftakher; Mohammadian, Mehrbod; Takala, Riikka S.K.; Tenovuo, Olli; Lagerstedt, Linnéa; Ala-Seppälä, Henna; Frantzén, Janek; van Gils, Mark; Hutchinson, Peter; Katila, Ari J.; Maanpää, Henna-Riikka; Menon, David K.; Newcombe, Virginia F.; Tallus, Jussi; Hrusovsky, Kevin; Wilson, David H.; Blennow, Kaj; Sanchez, Jean-Charles; Zetterberg, Henrik; Posti, Jussi P.
Source
Subject
*GLIAL fibrillary acidic protein
*BRAIN injuries
*RECEIVER operating characteristic curves
*CYTOPLASMIC filaments
*GLASGOW Coma Scale
*
*
*
*
Language
ISSN
0897-7151
Abstract
The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107 patients with mTBI (Glasgow Coma Scale ≥13) who had blood samples for GFAP and NF-L available within 24 h of arrival were included. Patients with mTBI were divided into computed tomography (CT)–positive and CT-negative groups. Glasgow Outcome Scale-Extended (GOSE) was used to assess the outcome. Outcomes were defined as complete (GOSE 8) versus incomplete (GOSE <8), and favorable (GOSE 5–8) versus unfavorable (GOSE 1–4). GFAP and NF-L concentrations in blood were measured using ultrasensitive single molecule array technology. Patients with incomplete recovery had significantly higher levels of NF-L compared with those with complete recovery (p = 0.005). The levels of GFAP and NF-L were significantly higher in patients with unfavorable outcome than in patients with favorable outcome (p = 0.002 for GFAP and p < 0.001 for NF-L). For predicting favorable outcome, the area under the receiver operating characteristic curve for GFAP and NF-L was 0.755 and 0.826, respectively. In a multi-variate logistic regression model, the level of NF-L was still a significant predictor for complete recovery (odds ratio [OR] = 1.008; 95% confidence interval [CI], 1.000–1.016). Moreover, the level of NF-L was a significant predictor for complete recovery in CT-positive patients (OR = 1.009; 95% CI, 1.001–1.016). The early levels of GFAP and NF-L are significantly correlated with the outcome in patients with mTBI. The level of NF-L within 24 h from arrival has a significant predictive value in mTBI also in a multi-variate model. [ABSTRACT FROM AUTHOR]