학술논문
Association between global functioning at first schizophrenia diagnosis and treatment resistance.
Document Type
Article
Author
Source
Subject
*DIAGNOSIS of schizophrenia
*COHORT analysis
*REGRESSION analysis
*ANTIPSYCHOTIC agents
*SOCIAL skills
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Language
ISSN
1751-7885
Abstract
Aim: Several factors such as age, gender, urbanicity and clinical treatment setting have been associated with treatment‐resistant schizophrenia (TRS). We examined the association between the Global Assessment of Functioning (social Functioning [GAF‐F]) score at first schizophrenia diagnosis and TRS and explored whether level of functioning could partially explain the known associations. Methods: A nationwide population‐based cohort study among individuals, who had a GAF‐F score at first schizophrenia diagnosis. We used adjusted Cox regression analysis to calculate hazard ratios (HRs). Results: Among 3252 individuals, severe functional impairment (GAF‐F ≤ 30) was associated with TRS within 2 years after diagnosis (adjusted HR = 1.38 [95% confidence interval: 1.03‐1.87). GAF‐F had virtually no impact on the associations between investigated known risk factors and TRS. Conclusions: GAF‐F was independently associated with TRS. Consideration of a global functioning score may help clinicians to detect treatment resistance earlier among individuals with schizophrenia. [ABSTRACT FROM AUTHOR]