부산대학교 도서관

Objective To understand the association between ovarian hormones, non-acute satiety hormones and craving calorie dense foods in the luteal phase. Methods 17 premenopausal women, mean age 23.2 y, mean BMI 22.4 kg/m 2 with regular menstrual cycles were studied during late follicular (FP) and luteal phases (LP). Estradiol, progesterone, DHEAS, SHBG, insulin and leptin, were measured in fasting samples. The validated Food Craving Inventory was used to record the types of foods volunteers habitually ate – rich in fat, carbohydrate or sweet taste, as well as craved during the LP of their menstrual cycle. Results Estradiol was inversely associated with leptin in FP ( r = − 0.62, p = 0.01). Leptin was inversely associated with habitual intake of sweet foods, in both phases (FP: r = − 0.64, p = 0.01; LP: r = − 0.63, p = 0.01). SHBG in LP was positively associated with craving sweet and carbohydrate rich foods. Hierarchical cluster analysis revealed two groups of women, one with high estradiol, high estradiol/leptin ratio, high sweet and carbohydrate cravings ( p < 0.05); the other group had lower estradiol, lower estradiol/leptin ratio, and reported less craving. Conclusions The estradiol-leptin axis may be a determinant of luteal phase craving and habitual food intake in menstruating women. Clinical Trial Registration Number: NCT01407692 [ABSTRACT FROM AUTHOR]