학술논문
Causal Relationships between Homocysteine and the Polycystic Ovary Syndrome: A Mendelian Randomization Analysis.
Document Type
Article
Author
Source
Subject
*HOMOCYSTEINE
*RISK assessment
*MOLECULAR epidemiology
*GENOME-wide association studies
*PREDICTION models
*HYPERHOMOCYSTEINEMIA
*EUROPEANS
*POLYCYSTIC ovary syndrome
*DESCRIPTIVE statistics
*ODDS ratio
*COMPARATIVE studies
*CONFIDENCE intervals
*SINGLE nucleotide polymorphisms
*DISEASE risk factors
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Language
ISSN
1687-8337
Abstract
Background. Polycystic ovary syndrome (PCOS) is an endocrine disease attributed to multiple genetic variants and environmental factors. We aimed to find the causal association of homocysteine (Hcy) with PCOS. Methods. A two-sample Mendelian randomization (MR) analysis was performed. We selected 14 single-nucleotide polymorphisms (SNPs) as instrumental variables to predict the risk of PCOS from genome-wide association studies (GWAS). The summary statistics of PCOS were obtained from 3 large genome-wide association studies in the European population, involving 4,138 cases and 20,129 controls, 3,609 cases and 229,788 controls, 994 cases and 165,817 controls, separately. Results. The IVM analyses revealed that plasma Hcy levels were not causally associated with the risk of PCOS in the meta-analysis (combined effect = 1.032, 95% confidence interval (CI): 0.885–1.203, p = 0.688). Conclusions. There was no sufficient evidence to support the causal association of the Hcy with the risk of PCOS. [ABSTRACT FROM AUTHOR]