학술논문
Common sequence variants on 20q11.22 confer melanoma susceptibility.
Document Type
Article
Author
Brown, Kevin M.; MacGregor, Stuart; Montgomery, Grant W.; Craig, David W.; Zhen Zhen Zhao; Iyadurai, Kelly; Anjali K. Henders; Homer, Nils; Campbell, Megan J.; Stark, Mitchell; Thomas, Shane; Schmid, Helen; Holland, Elizabeth A.; Gillanders, Elizabeth M.; Duffy, David L.; Maskiell, Judith A.; Jetann, Jodie; Ferguson, Megan; Stephan, Dietrich A.; Cust, Anne E.
Source
Subject
*GENOMES
*MELANOMA
*CHROMOSOMES
*DISEASE risk factors
*GENETICS
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Language
ISSN
1061-4036
Abstract
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 × 10−15). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases. [ABSTRACT FROM AUTHOR]