학술논문
Increased expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in Wegener's granulomatosis—possible role in vascular inflammation.
Document Type
Article
Source
Subject
*CHEMOKINES
*CYTOKINES
*GRANULOMATOSIS with polyangiitis
*KIDNEY diseases
*RESPIRATORY diseases
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Language
ISSN
1462-0324
Abstract
Objective. Based on the function of fractalkine (CX3CL1), the unique member of the CX3C chemokine subfamily, in endothelial-related inflammation, we hypothesized a role for CX3CL1 and its receptor (CX3CR) in Wegener's granulomatosis (WG). In the present study, this hypothesis was tested by different experimental approaches. [ABSTRACT FROM PUBLISHER]