학술논문
Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery.
Document Type
Article
Author
Alwan, Heba; Ware, Julia; Boughton, Charlotte K.; Wilinska, Malgorzata E.; Allen, Janet M. (NURSE); Lakshman, Rama; Nwokolo, Munachiso; Hartnell, Sara; Bally, Lia; de Beaufort, Carine; Besser, Rachel E.J.; Campbell, Fiona M.; Davis, Nikki; Denvir, Louise; Evans, Mark L.; Fröhlich-Reiterer, Elke; Ghatak, Atrayee; Hofer, Sabine E.; Kapellen, Thomas M.; Leelarathna, Lalantha
Source
Subject
*HYPOGLYCEMIA
*INSULIN
*TYPE 1 diabetes
*AGE groups
*AGE differences
*
*
*
*
Language
ISSN
1520-9156
Abstract
Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2–7 years), children and adolescents (8–18 years), adults (19–59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4–5.0]) and very young children (4.0% [3.4–5.2]), followed by adults (2.7% [1.7–4.0]), and older adults (1.8% [1.2–2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight–05:59) was lower than during daytime (06:00–23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups. [ABSTRACT FROM AUTHOR]