학술논문
Exceptional biocompatibility of 3D fibrous scaffold for cardiac tissue engineering fabricated from biodegradable polyurethane blended with cellulose.
Document Type
Article
Source
Subject
*POLYURETHANES
*TISSUE scaffolds
*BIOCOMPATIBILITY
*TISSUE engineering
*FABRICATION (Manufacturing)
*BIODEGRADABLE materials
*POLYMER blends
*CELLULOSE
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Language
ISSN
0091-4037
Abstract
The auhtors report 3D biomimetic scaffolds using polymer blend of polyurethane and cellulose for cardiac tissue engineering. The biocompatible and biodegradable polyurethane is designed, synthesized and characterized. By incorporating 10 wt% of naturally ordered cellulose into the polyurethane and electrospinning them into 3D scaffold, the scaffold exhibits good biocompatibility and mechanical property to support and accommodate constant cycles of contraction/expansion of cardiac tissue. The biocompatibility is further improved using scaffold fabricated from aligned fibers due to synergistic effects between cells and ordered macromolecules. The anisotropic structured scaffold is mimicked the extracellular matrix and has therapeutic potential in reconstruction of damaged myocardium. [ABSTRACT FROM PUBLISHER]