학술논문
Association of IL-22 and IL-22RA1 gene variants in Iranian patients with colorectal cancer.
Document Type
Article
Author
Source
Subject
*CYTOKINES
*SINGLE nucleotide polymorphisms
*GENETIC variation
*CASE-control method
*ALLELES
*COLORECTAL cancer
*CANCER patients
*CELLULAR signal transduction
*RISK assessment
*DISEASE susceptibility
*GENOTYPES
*POLYMERASE chain reaction
*DISEASE risk factors
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Language
ISSN
2008-2258
Abstract
Aim: In the current study, it was hypothesized that single nucleotide polymorphisms (SNPs) in the regulatory region of the IL-22 signaling pathway genes, including IL-22 and IL-22RA1 variants, may be associated with CRC susceptibility. Background: The important role of pro-inflammatory cytokines during tumorigenesis is well-established. In recent years, IL-22 has been linked with colorectal cancer (CRC) through a number of mechanistic and observational studies Methods: The association of four polymorphisms in the IL-22 (rs1179251 and rs1179246) and IL-22RA1 (rs4648936 and rs10794665) genes with CRC risk were studied using a case-control design with 304 cases and 345 controls from the Iranian population. All 649 subjects were evaluated by PCR-RFLP method. Results: No significant difference was found in genotype and allele frequencies between the cases and controls for either IL-22 and IL-22RA1 gene variants or CRC risk before or after adjusting for confounders. Conclusion: The current findings do not present any significant evidence for associations between variants in IL-22 signaling pathway genes and CRC. Complementary studies with greater sample sizes may be necessary to fully elucidate the nature of these associations. [ABSTRACT FROM AUTHOR]