부산대학교 도서관

Introduction. Neuromyelitis optica spectrum disorders (NMOSD) are rare antibody-mediated disorders of the central nervous system with a predilection for the spinal cord and optic nerves. The clinical utility of evoked potential recordings (EPs) has already been established for multiple sclerosis, in particular, the abnormal visual evoked potentials (VEP) a key criterion in the McDonald diagnostic criteria for MS. On the other hand, there have been few reports on EPs in patients with NMOSD. Methods. The VEP were prospectively performed in 13 patients with NMOSD. All the patients were recruited from the outpatient clinic of a demyelinating diseases center. The recorded was done as recommended by the International Federation of Clinical Neurophysiology. All studies were conducted in accordance with ethical principles after obtaining patient informed consent. Results. We evaluated 12 women with mean age of 42 years old and one man of 25 years old. In 6 the examined eye, a response was not obtained. In the remaining 20, we found a significant increase in P100 latency without amplitude change. The relation to the VEP variable (Normal vs Abnormal), there was a statistical difference in relation to P100 Oc latencies. Conclusion. VEP is a well-known noninvasive tool for investigating the function of the visual system. Decreased amplitude and prolonged latency of VEP recording is believed to reflect the damage of axon and demyelination in the optic nerve. VEP showed a significant increase in P100 latency. VEP is a non-invasive, painless, fast and low-cost exam which provides neurophysiological data for diagnosis of NMOSD. Our results reinforce the concept of VEP evaluation is currently the standard method used to confirm the presence of clinical and subclinical Optic Neuritis. [ABSTRACT FROM AUTHOR]