학술논문
THE ENCAPSULATION OF METFORMIN ON CHITOSAN MATRIX AS DIABETES MELLITUS DRUG SLOW RELEASE SYSTEM.
Document Type
Article
Source
Subject
*METFORMIN
*DIABETES
*CHITOSAN
*TYPE 2 diabetes
*ROUGH surfaces
*SURFACE morphology
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Language
ISSN
0974-1496
Abstract
This study was aimed to encapsulation metformin, the diabetes melittus type 2 drugs. In this study, chitosan-alginat and tween 80 composites were used as matrix encapsulation. The chitosan was mixed with variation of the composition of metformin- calcium alginate- tween 80. The effectivity of encapsulation was evaluated from surface morphology, functional group, % drug encapsulation efficiency and effect soaked on stability encapsulation. The metformin encapsulated was characterized to analysis of the functional group and particle size. The results showed that the metformin encapsulated a slightly rough surface with a good appearance. The drug encapsulation efficiency was about 7.06 to 30.32%. [ABSTRACT FROM AUTHOR]