학술논문
Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development.
Document Type
Article
Author
Source
Subject
*IMMUNOGLOBULINS
*INTERFERONS
*MULTIPLE sclerosis
*TITERS
*DRUG resistance
*BIOMARKERS
*PATIENTS
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Language
ISSN
1352-4585
Abstract
The article presents a study of the potential of early binding antibody (BAb) titers or different interferon-beta (IFN-b) biomarkers to predict neutralizing antibodies (NAb). The study included patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS) that receive de novo IFN-b treatment. Results showed that BAb titers reliably predict Nabs, with CXCL-10 as a potential sensitive biomarker for IFN-b response and abrogation by anti-IFN-b antibodies.