학술논문
Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group.
Document Type
Letter
Author
Source
Subject
*RENIN-angiotensin system
*COHORT analysis
*ACUTE myeloid leukemia in children
*NUCLEOTIDE sequence
*DISEASE remission
*DISEASE incidence
*GENETIC polymorphisms
*GENETICS
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Language
ISSN
0887-6924
Abstract
The article presents a study which focuses on the incidence and prognostic significance of NRAS mutation (NRASmut) in a cohort of children with acute myeloid leukemia (AML). 1241 eligible patient have enrolled on CCG-2961 and COG-AAML03P1 wherein diagnostic DNA was made available for 825 children. The researchers have failed to demonstrate the presence of NRASmut in the remission specimens but only the NRASmuts are disease-associated mutations and not germline polymorphisms.