학술논문
Interplay between p53 and VEGF: how to prevent the guardian from becoming a villain.
Document Type
Article
Author
Source
Subject
*VASCULAR endothelial growth factors
*P53 protein
*FIBROBLASTS
*HYPOXEMIA
*LABORATORY mice
*NEOVASCULARIZATION
*
*
*
*
*
Language
ISSN
1350-9047
Abstract
The authors comment on a study published within the issue which showed that induction of vascular endothelial growth factor (VEGF) transcription during acute hypoxia occurred in a p53-dependent manner in non-transformed mouse embryo fibroblasts (MEF). They discuss the clinical relevance of the mechanisms dictating the distinct VEGF expression in acute and chronic hypoxic responses. The author also explain the critical importance of VEGF in dictating angiogenesis.